Author/Authors :
Asadzadeh Aghdaei, Hamid Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Ghasemi, Faranak Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Nooraliee, Mina Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Sadegh Fazeli, Mohammad Department of surgery - Imam Khomeini Medical complex - Tehran University of Medical Sciences, Iran , Anaraki, Fakhrosadat Colorectal Division of Department of Surgery - Taleghani Hospital -Shahid Beheshti University of Medical Sciences, Tehran, Iran , Sorrentino, Dario IBD Center - Department of Medicine - Division of Gastroenterology - Virginia Tech Carilion School of Medicine, Roanoke, VA, USA , Balaii, Hedieh Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Shahrokh, Shabnam Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Aim: The aim of this study was to explore the quality of life (QoL) in a group of patients who had an intractable disease on medical
therapy including biologics and underwent surgery.
Background: Quality of life of patients with ulcerative colitis (UC) has been measured with a series of multiple questionnaires
Methods: An observational cross sectional study was carried out on 68 patients with documented UC referring to an IBD clinic in a
tertiary hospital. Patients with UC who had a colectomy because of intractable disease and were in remission for a year were eligible
for enrollment Patients were instructed to fill the SF-36 Questionnaire (interviewer-administered) regarding quality of life. Side
effects were evaluated with another questionnaire. Results were compared with the normal population of the community.
Results: In comparison with normal population, patients having colectomy have better general QoL. Impotency and incontinency
were most common adverse events after colectomy while the adverse events that decreased the QoL significantly were anal secretions
and number of bowel movements per day without using antidiarrheal- drugs.
Conclusion: In conclusion, our study showed a significant improvement of general QoL in a selected group of UC patients, who were
in clinical remission following IPAA and only number of bowel movements per day and anal secretions significantly impaired their
QoL. We suggest that a disease-specific questionnaire should be designed, making changes in health-related QOL more detectable
over time, since it is more sensitive to these changes in IBD patients than a general questionnaire.
