Fe3O4 magnetic nanoparticles (MNPs) as an effective catalyst for synthesis of indole derivatives

The principal aim of this research is the application of Fe3O4 (MNPs) in the synthesis of some indole derivatives. Fe3O4 MNPs were prepared by CoPrecipitation method from the reaction of FeCl2.4H2O and FeCl3.6H2O in ammonia solution. Morphology and structure of Fe3O4 MNPs were determined by FT-IR, XRay diffraction (XRD), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Fe3O4 (MNPs) has been used as a highly efficient catalyst for the synthesis of some Indole derivatives like 6HIndole [2,3b] quinoxaline, 3-methyl–6HIndole [2,3b] quinoxaline and (z)3-(pyridine-2-ylimino)Indole2one. The reaction was carried out using various amounts of Fe3O4 nanoparticles in various solvents and solventfree conditions. The optimum amount of nanoFe3O4 was 5 mol% in THF under reflux conditions. The structures of indole derivatives were further established by NMR, and FTIR spectra. In view of excellent catalytic capacity, the exceedingly simple workup procedure, environmentally friendly reaction and good yield, Fe3O4 (MNPs) was proved to be the good catalyst for this reaction.