Author/Authors :
Molaei, Mahsa Pathology Department - Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Ehtiati, Ara Department of Pathology - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Mashayekhi, Reza Pathology Department - Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Rafizadeh, Mitra Department of Pathology - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Zojaji, Homayoun Pathology Department - Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Mirsattari, Dariush Pathology Department - Gastroenterology and Liver Diseases Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Kishani Farahani, Roya Basic and Molecular Epidemiology of Gastroenterology Disorders Research Center - Research Institute for Gastroenterology and Liver Diseases - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Aim: This study used the OLGA system to characterize the histology pattern of gastritis in dyspeptic outpatients with a
mean age of 45 years from regions with different gastric cancer risks.
Background: Several classification systems have been purposed for understanding the status of the gastric mucosa.
Currently, the Sydney system is the most widely employed. Nevertheless, the applicability of the Sydney system in
therapeutic and prognostic areas is a matter of debate. Given this shortcoming an international group of
gastroenterologists and pathologists developed a new system named Operative Link on Gastritis Assessment (OLGA).
Patients and methods: In this cross-sectional comparative study the OLGA system was used to characterize the
histology pattern of gastritis in 685 dyspeptic patients referring to the department of gastroenterology of a training
hospital.
Results: No significant correlation was found between active inflammation and total OLGA score (P > 0.05). Also, no
statistically significant correlation was found between activity and intestinal metaplasia, dysplasia, atrophy, and cancer
(P > 0.05). Even though, there is a positive correlation between mild chronic inflammation and total OLGA score, no
correlation has been identified between chronicity and dysplasia or cancer (P > 0.05). Nearly, In all cases with no
dysplasia OLGA score was zero but all patients with gastric cancer OLGA score was more than two.
Conclusion: Generally, the activity is not a useful factor in predicting prognosis and its loss of relation with total OLGA
score does not make OLGA score any less predictable.
Keywords :
Chronic gastritis , Atrophy , Intestinal metaplasia , Staging
