Author/Authors :
MotamediRad, Neda Hormozgan University of Medical Sciences, Bandar Abbas, Iran. , Rezaeishamirzadi, Meysam Hormozgan University of Medical Sciences, Bandar Abbas, Iran. , Moosavy, Hamid Department of Internal Medicine - Hormozgan University of Medical Sciences, Bandar Abbas, Iran , Shekari, Mohammad Department of Genetics - Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Abstract :
Introduction: Helicobacter pylori is the main cause of chronic inflammation and peptic
ulcer. More than half of the world population is afflicted with Helicobacter, while only
20% of people show the clinical symptoms of the disease. Genes encoding the cytokines
interleukin (IL)-1B play a key role in the inflammatory responses of gastric mucus. This
study aims to analyze polymorphism in the IL-1B gene.
Methods: 107 individuals who showed the symptoms of chronic gastritis participated in
the treatment group. Individuals with no symptoms were considered as the control group. IL-1B+3954C/T polymorphism was analyzed through PCR-RFLP.
Results: There is no association between the presence of the T allele in an IL-1B gene
whit peptic ulcer and chronic gastritis as compared with control group (OR=0.66,
CI=0.34-1.27, OR=0.75, CI=0.32-1.15) respectively.
Conclusion: Our results suggest that there is no association between IL-1B+3954 C/T
polymorphism and peptic ulcer disease and chronic inflammation.
