Evaluation of frequency polymorphism Interleukin 1B gene in patients with peptic ulcer and chronic gastritis

Introduction: Helicobacter pylori is the main cause of chronic inflammation and peptic ulcer. More than half of the world population is afflicted with Helicobacter, while only 20% of people show the clinical symptoms of the disease. Genes encoding the cytokines interleukin (IL)-1B play a key role in the inflammatory responses of gastric mucus. This study aims to analyze polymorphism in the IL-1B gene. Methods: 107 individuals who showed the symptoms of chronic gastritis participated in the treatment group. Individuals with no symptoms were considered as the control group. IL-1B+3954C/T polymorphism was analyzed through PCR-RFLP. Results: There is no association between the presence of the T allele in an IL-1B gene whit peptic ulcer and chronic gastritis as compared with control group (OR=0.66, CI=0.34-1.27, OR=0.75, CI=0.32-1.15) respectively. Conclusion: Our results suggest that there is no association between IL-1B+3954 C/T polymorphism and peptic ulcer disease and chronic inflammation.