Changes in fibrinogen levels, plasma viscosity and insulin resistance after 4 weeks of combined sit-up and walking training

Introduction: Reports concerning the association of physical activity with markers of inflammation, coagulation, and fibrinolysis are ambiguous. The aim of this study was to assess the effect of 4 weeks of combined decomposedsit-up and walking training with two different volumes onfibrinogen, plasma viscosity and insulin resistance index (HOMA-IR) in college, young men. Methods: In this semi-experimental study, 18 subjects with age range 19 to 25 years selected as research subjects and were randomly divided into two groups including; group 1 (15 min sit-up -30 min run) and group 2 (30 min sit-up -15 min run). The study sit-up training included 25 types of training for abdominal muscles and the walking intensity was 130-140 steps per minute. Blood samples were collected before and after 4 weeks (16 sessions) and the levels of fibrinogen, plasma viscosity and HOMA-IR were measured. Data analyzed by two ways ANOVA (Between-group changes) and paired T-test. Results: Compared with the pre-test, both groups demonstrated a significant reduction in body weight over the course of the study (P<0.05). BMI for the group 2 (30 minute sit-up +15 minute walking) in the post-test decreased significantly compared with the pre-test (P=0.037). In the post-test fibrinogen levels (P=0.008) and plasma viscosity (P=0.008) decreased significantly only in the group 2. The two-way ANOVA showed a significant difference between the two groups only in the levels of fibrinogen (P=0.024). Conclusion: The current research findings indicate that fibrinogen and plasma viscosity levels in group 2 (30 minute sit-up +15 minute walking) decreased compared with the pre-test after 4 week of training; but fibrinogen and plasma viscosity levels in the group 1 (15 minute sit-up +30 minute walking) did not change significant.