Title of article :
Lineage Switch in Childhood Leukemia: A Case Report and Review of Literature
Author/Authors :
Nazari, Shiva Pediatric Congenital Hematologic Disorders Research Center - Mofid Children’s Hospital - Shahid Beheshti University of Medical Sciences, Tehran , Malek, Fatemeh Pediatric Respiratory Diseases Research Center - National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences, Tehran , Zavvar, Navid Pediatric Congenital Hematologic Disorders Research Center - Mofid Children’s Hospital - Shahid Beheshti University of Medical Sciences, Tehran
Abstract :
Acute leukemia which is the most common cancer in children is a heterogeneous
group of clonal malignancies. The conversion of the leukemic cell lineage
during the course of the disease or later is termed lineage switch. It has been
rarely reported in the literature. In leukemia lineage switch, conversions from
lymphoblastic leukemia to myeloid leukemia or vice versa are reported. Herein,
we report a 7-year-old child with acute lymphoblastic leukemia which switched
to acute myeloid leukemia upon relapse.
Keywords :
Leukemia , Children , Cell lineage
Journal title :
Iranian Journal of Blood and Cancer (IJBC)
