Title of article :
The Role of Adiponectin in Prostate Cancer: A Narrative Review
Author/Authors :
Sheikhpour, Robab Hematology and Oncology Research Center - Shahid Sadoughi University of Medical Sciences, Yazd
Abstract :
Prostate cancer (PCa) is the most common type of cancer among men over
60 years old. The aggressiveness and mortality of PCa can be correlated with
obesity. Adipose tissue-derived cytokines such as adiponectin may explain the
correlation between PCa and obesity. Since the correlation between adiponectin
and aggressive PCa is still not fully evaluated, we aimed to investigate the
probable role of adiponectin in PCa. Adiponectin is considered as a link between
obesity, insulin resistance and diabetes. On the other hand, adiponectin is a key
mediator of systemic insulin sensitivity and glucose homeostasis. Moreover,
low level of adiponectin is associated with inflammation and angiogenesis.
These processes could promote tumor growth. Special effects of adiponectin
are mediated via adenosine monophosphate-activated protein kinase (AMPK).
AMPK activation inhibits growth of androgen-independent and androgensensitive PCa cell lines. Moreover, c-Jun N-terminal protein kinase (JNK) and
Signal transducer and activator of transcription 3 (STAT3) signaling pathway
are known as adiponectin’s mediators on the metabolic syndrome and cancer.
Furthermore, adiponectin acts as a tumor suppressor gene via inhibition of
Epithelial-to-mesenchymal Transition (EMT) of PCa cells, but it is down
regulated through hypermethylation of promoter gene in PCa cells. Therefore,
according to the results of these studies, decreased concentration of adiponectin
was associated with increased risk of PCa. It seems that hypoadiponectinemia
may act as a promising biomarker for detection and diagnosis of PCa.
Keywords :
Adiponectin , Prostate cancer , Obesity , Hyperinsulinemia , Early detection
Journal title :
Iranian Journal of Blood and Cancer (IJBC)