Author/Authors :
Shahramian, Iraj Department of Pediatric - Zabol University of Medical Sciences, Zabol , Haghighat, Mahmood Department of Pediatric Gastroentrology - Shiraz University of Medical Sciences, Shiraz , Noori, Noor Mohammad Zahedan Medical University, Zahedan , Teimouri, Ali Reza Zahedan Medical University, Zahedan , Sharafi, Elham Zahedan Medical University, Zahedan , Kalili, Manijeh Zahedan Medical University, Zahedan , Ataollahi, Maryam Department of Pediatric Gastroentrology - Shiraz University of Medical Sciences, Shiraz , Bahmanyar, Maryam Department of Pediatric Gastroentrology - Shiraz University of Medical Sciences, Shiraz
Abstract :
Background: It is suggested that constipation could be due to celiac disease (CD); therefore, this
study aimed to determine the prevalence of positive tissue transglutaminase (tTG) IgA test among
children with functional constipation (FC).
Methods: In this case-control study, 182 consecutive patients with FC who fulfilled the Rome
III criteria as cases were compared with 240 healthy children as the control group in terms of
suspicious CD by measuring the serum tTG IgA level.
Results: There was a significant difference in favor of the case group in terms of serum tTG IgA
levels (P = 0.000). The probability of having CD would change based on belonging to each group
(case/control odds ratio [OR] = 0.222).
Conclusion: With respect to these data, tTG IgA level was observed to be significantly higher in
patients relative to healthy children; therefore, it is recommended that patients be screened for
CD through the tTG IgA.
Keywords :
Functional constipation , Celiac , Tissue transglutaminase , IgA
