Author/Authors :
Nasiri, Aliakbar Department of Anesthesiology - Zabol University of Medical Sciences, Zabol , Afsar Gharebagh, Roghayeh Department of Cardiology - Urmia University of Medical Sciences, Urmia , Nojoumi, Ali graduate , Akbarizadeh, Majidreza Department of Pediatrics - Zabol University of Medical Sciences, Zabol , Harirchi, Sharareh Department of Microbiology - Isfahan University of Medical Sciences, Isfahan , Arefnezhad, Masoud Zabol University of Medical Sciences, Zabol , Sahraei, Shahla Zabol University of Medical Sciences, Zabol , Hesaraki, Mehran Department of Pediatrics - Zabol University of Medical Sciences, Zabol , Afshari, Mahdi Zabol University of Medical Sciences, Zabol , Javadian, Fereshteh Zabol University of Medical Sciences, Zabol , Sheykhzade Asadi, Maryam Islamic Azad University, Kerman , Shahi, Zahra Islamic Azad University, Kerman , Sargazi, Aliyeh Zabol University of Medical Sciences, Zabol
Abstract :
Background: Antimicrobial resistance is one of the major characteristics of infectious agents.
Silver nanoparticles (AgNPs) have been introduced as novel antibacterial agents in accordance
with the traditional treatments. Our purpose of this study was to evaluate the antimicrobial
activity of AgNPs on the Pseudomonas aeruginosa (P. aeruginosa) that are resistant to antibiotics.
Methods: During a cross-sectional study, we tried to evaluate 20 strains of P. aeruginosa isolated
from the urine cultures of patients admitted to the hospital due to urinary tract infections. The
AgNPs were commercially purchased. The minimum inhibitory concentration (MIC) of AgNPs
in different concentrations was determined by the dilution in wells on bacteria. The antibiotic
susceptibility pattern of P. aeruginosa was evaluated by the Kirby-Bauer disk diffusion standard.
Results: Current study indicated that P. aeruginosa were resistant to four types of agents including
ampicillin (85%), nitrofurantoin (65%), nalidixic acid (65%), and ciprofloxacin (15%) and result
of nanosilver indicated that the most MIC was 100 ppm concentration, and six strains of P.
aeruginosa were inhibited by it.
Conclusion: Our study presented a new type of silver nanoparticle and indicated that they can
be embedded in bone cement to prevent infections once synthetic conditions are tailored for
such applications.
Keywords :
Nanosilver , Antimicrobial activity , Pseudomonas aeruginosa , Minimum inhibitory concentrations (MIC) , Antibiotic-resistant
