Author/Authors :
Maryam, Yaghobi Pregnancy Health Research Center - Zahedan University of Medical Sciences (ZUMS), Zahedan, Iran , Miri-Moghaddam, Ebrahim Genetics of Non-Communicable Disease Research Centre, ZUMS, Zahedan, Iran , Naderi, Majid Genetics of Non-Communicable Disease Research Centre, ZUMS, Zahedan, Iran , Ali, Bazi Clinical Research Development Unit - Amir-Al-Momenin Hospital - Zabol University of Medical Sciences, Zabol, Iran , Navidian, Ali Department of Mental Health & Psychiatric Nursing - Pregnancy Health Research Centre, ZUMS, Zahedan, Iran , Asiyeh, Kalkali Students Scientific Research Center - Faculty of Nursing & Midwifery - ZUMS - Iran Hospital, Iranshhar, Iran
Abstract :
Background: Thalassemia syndromes are among prevalent hereditary disorders imposing high expenses on health-care system worldwide and in Iran. Organ failure represents a life-threatening challenge in transfusion- dependent β-thalassemia (TDT) patients. The purpose of the present study was to determine the frequency of organ dysfunctions among TDT patients in Sistan and Baluchistan province in South-East of Iran.
Methods: Laboratory and clinical data were extracted from medical records as well as by interviews. Standard criteria were applied to recognize cardiac, gonadal, endocrine and renal dysfunctions. The collected data were analyzed using the SPSS statistics software (Ver.19).
Results: A total of 613 TDT patients (54.3% males and 45.7% females) were included in this study. The mean age of patients was 13.3± 7.7 years old. Cardiac events comprised the most encountered complications (76.4%), following by hypogonadism (46.8%), parathyroid dysfunction (22%), thyroid abnormalities (8.3%), diabetes (7.8%) and renal disease (1.8%). Hypogonadism comprised the most identified complication in patient <15 years old, while the cardiac complications were the most frequent sequela in patients >15 years old (P<0.01).
Conclusion: As cardiac events are significantly more common among TDT patients, close monitoring of the heart function is recommended for identifying patients with cardiac problems.
Keywords :
Cardiac disease , Organ dysfunction , Iron overload , β- thalassemia major