Title of article :
Manifestly Altered MicroRNAs in Poly Cystic Ovary Syndrome
Author/Authors :
Moraghebi ، Mahta Student Research Committee, Faculty of Medicine - Hormozgan University of Medical Sciences , Rafat ، Milad Student Research Committee, Faculty of Medicine - Hormozgan University of Medical Sciences , Mousavi ، Pegah Department of Medical Genetics - Faculty of Medicine - Hormozgan University of Medical Sciences , Malekzadeh ، Kianoosh Department of Medical Genetics - Faculty of Medicine - Hormozgan University of Medical Sciences
Abstract :
MicroRNAs (miRNAs) constitute a large family of small non-coding RNAs which regulate gene expression at the surface following transcription. They are widely involved in many physiological and pathological processes including polycystic ovarian syndrome (PCOS). PCOS is an endocrine disorder in women. Currently, there is no comprehensive information about the role of miRNAs in PCOS. Thus, this paper has attempted to collate studies on miRNAs in order to determine important changes in their miRNA expression profile in the total blood, serum, plasma, follicular fluid, and granulosa cells in PCOS patients alongside the genes which are targeted for regulation by these miRNAs. This study presents a new approach for using miRNAs and their target genes for diagnosing and treating PCOS.
Keywords :
MicroRNA , Small non , coding RNA , Polycystic ovary cancer
Journal title :
Disease and Diagnosis
Journal title :
Disease and Diagnosis
