Synthesis and Antibacterial Activity Study of 2-[(2,6 -dichlorophenyl amino)-phenyl]-acetic acid Derivatives with Various Sulfonamides

Various 30 sulfonamides derivatives of 2-[(2,6-dichlorophenylamino)- phenyl]-acetic acid (5) have been prepared via two steps. The antibacterial activity studies for all new derivatives have been performed on both Gram positive S. aureus, B. subtilis and Gram negative E. coli, P. vulgaris bacteria, when compared with the results obtained from standard drugs penicillin, chloramphenicol, and ampicillin. The antibacterial obtained results were found to be quite satisfactorily compared with the standard drugs. The final compounds were characterized by IR, 1H-NMR spectra and elemental analysis.