Neat Reaction Technology and Conventional Method for the Synthesis of 4-Oxo-Thiazolidines and their 5-Arylidene Derivatives and its Antimicrobial Activity

Several new 4-arylideneamino-3-mercapto-5-[(phenothiazin-10-yl) methyl]-1,2,4-triazoles 5a-h, 2-aryl-3-(3-mercapto-5-phenothiazin-10-ylmethyl-[1,2,4]-triazol-4-yl)-thiazolidin-4-one 6a-h and 5-arylidene-2-aryl-3-(3-mercapto-5-phenothiazin-10-ylmethyl-[1,2,4]-triazol-4-yl)-thiazolidin-4-one 7a-h were synthesized under both conventional as well as microwave irradiation technique. The structures of all synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, FAB- mass spectra and by microanalytical data. All synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, Salmonella typhi and Bacillus subtilis and antifungal activity against Aspergillus flavus, Fusarium oxysporum and Penicillium citrinum. Some of the compounds have shown significant antibacterial and antifungal activities.