Author/Authors :
Zununi Vahed, Sepideh School of Advanced Biomedical Sciences - Tabriz University of Medical Sciences, Tabriz, Iran , Samadi, Nasser School of Advanced Biomedical Sciences - Tabriz University of Medical Sciences, Tabriz, Iran , Mostafidi, Elmira Department of Pathology Imam Reza Hospital - Tabriz University of Medical Sciences, Tabriz, Iran , Ardalan, Mohammadreza Kidney Research Center - Tabriz University of Medical Sciences, Tabriz, Iran
Abstract :
Chronic allograft dysfunction is the most common cause of allograft
lost. Chronic allograft dysfunction happens as a result of complex
interactions at the molecular and cellular levels. Genetic and
environmental factors both influence the evolution and progression
of the chronic allograft dysfunction. Epigenetic modification could
be considered as a therapeutically modifiable element to pause
the fibrosis process through novel strategies. In this review, the
PubMed database was searched for English-language articles on
these new areas.
Keywords :
fibrosis , genetic , epigenetic , chronic allograft dysfunction
