Author/Authors :
Zaare Nahandi, Maryam Chronic Kidney Disease Research Center - Sina Educational Hospital - Tabriz University of Medical Sciences, Tabriz, Iran , Ardalan, Mohamad Reza Chronic Kidney Disease Research Center - Sina Educational Hospital - Tabriz University of Medical Sciences, Tabriz, Iran , Banagozar Mohamadi, Ali Medical Philosophy and History Research Center - Department of Toxicology - Sina Educational Hospital - Tabriz University of Medical Sciences, Tabriz, Iran , Ghorbani Haghjo, Amir Tabriz University of Medical Sciences, Tabriz, Iran , Jabbarpor Bonyadi, Morteza Center of Excellence for Biodiversity - School of Natural Sciences - Tabriz University, Tabriz, Iran , Mohamadian, Tahere Center of Excellence for Biodiversity - School of Natural Sciences - Tabriz University, Tabriz, Iran
Abstract :
Introduction. The kidney is the main source of serum Klotho
production. Immunosuppressive agents could affect the kidney
in this regard. The effect of the ACE gene polymorphism on
Klotho production is a less studied area. This study aimed to
assess serum Klotho and ACE gene in a group of stable kidney
transplant recipients.
Materials and Methods. In a cross-sectional study, 30 kidney
transplant recipients with stable allograft function and 27 healthy
young individuals were assessed for their serum Klotho levels. The
ACE gene polymorphisms were studied in both groups.
Results. Klotho level was higher in kidney transplant recipients
than the controls, but the difference was not significant (2.76 ± 2.41
ng/mL versus 2.01 ± 1.41 ng/mL, respectively). In both groups,
serum Klotho level was higher in those with the I>I polymorphism,
the men, those with higher glomerular filtration rate, and younger
individuals, but the differences did not reach a significant level.
Higher body mass index was significantly associated with lower
serum Klotho level in both groups.
Conclusions. Klotho level after kidney transplantation meets the
range in healthy individuals, and it is not affected by the ACE
gene polymorphism.
