Author/Authors :
Tajbakhsh, Ramin Non-communicable Diseases Research Center - Alborz University of Medical Sciences, Karaj, Iran , Heshmat, Ramin Chronic Diseases Research Center - Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran , Safiri, Saeid Managerial Epidemiology Research Center - Department of Public Health - School of Nursing and Midwifery - Maragheh University of Medical Sciences, Maragheh, Iran , Vafaeenia, Mahya Chronic Diseases Research Center - Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran , Motlagh, Mohammad Esmaeil Department of Pediatrics - Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , Mansourian, Morteza Health Management and Economics Research Center - Department of Health Education and Promotion - School of health - Iran University of Medical Sciences, Tehran, Iran , Beshtar, Shaghayegh School of Allied Medical Science - Iran University of Medical Sciences, Tehran, Iran , Safari, Omid Non-communicable Diseases Research Center - Alborz University of Medical Sciences, Karaj, Iran , Asayesh, Hamid Department of Medical Emergencies - Qom University of Medical Sciences, Qom, Iran , Ansari, Hossein Health Promotion Research Center - Department of Epidemiology and Biostatistics, Zahedan University of Medical Sciences, Zahedan, Iran , Qorbani, Mostafa Endocrinology and Metabolism Research Center - Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran , Kelishadi, Roya Department of Pediatrics - Child Growth and Development Research Center - Research Institute for Primordial Prevention of Noncommunicable Disease - Isfahan University of Medical Sciences, Isfahan, Iran
Abstract :
Introduction. This study aimed to assess the association of
glomerular filtration rate (GFR) with cardiometabolic risk factors
in Iranian adolescents.
Materials and Methods. Data of the 3rd round of a schoolbased
surveillance system entitled “Childhood and Adolescence
Surveillance and PreventIon of Adult Non-communicable Disease
(CASPIAN III)” study was used for this study. A sample of 367
adolescents aged between 10 and 18 years was randomly selected.
Glomerular filtration rate was estimated using the original and
the updated Schwartz equations. The association of GFR with
anthropometric data, blood pressure, lipid profile, and blood
glucose was assessed in boys and girls by age group.
Results. Of the participants, 50.4% were boys and 26.2% were from
rural regions. In the age group of 14 to 18 years, the ratio of lowto
high-density lipoprotein cholesterol was significantly lower in
the girls than the boys (P < .001), and the girls had significantly
higher triglyceride and FBG levels. Significant correlations were
found between GFR and waist circumference (r = 0.150 and P = .009
with the original Schwartz; r = 0.190 and P < .001 with the updated
Schwartz) and body mass index (r = 0.115 and P = .03 with the
original Schwartz; r = 0.121 and P = .02 with the updated Schwartz).
Conclusions. The above findings showed that obese and overweight
Iranian adolescents were more likely to have lower kidney function.
Strategies to decline impaired kidney function may include
prevention of obesity and central obesity in this population.
Keywords :
risk factors , obesity , kidney dysfunction , glomerular filtration rate , adolescents , Iran
