Author/Authors :
Ramezani-Jolfaie, Nahid Nutrition and Food Security Research Center - Shahid Sadoughi University of Medical Sciences, Yazd - Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd , Aghaei, Shiva Stem Cell Biology Research Center - Yazd Reproductive Sciences Institute - Shahid Sadoughi University of Medical Sciences, Yazd , Farashahi Yazd, Ehsan Stem Cell Biology Research Center - Yazd Reproductive Sciences Institute - Shahid Sadoughi University of Medical Sciences, Yazd , Moradi, Ali Department of Biochemistry and Molecular Biology - Faculty of Medicine - Shahid Sadoughi University of Medical Sciences, Yazd , Mozaffari-Khosravi, Hassan Yazd Diabetic Research Center - Shahid Sadoughi University of Medical Sciences, Yazd - Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd , Amiri, Mojgan Nutrition and Food Security Research Center - Shahid Sadoughi University of Medical Sciences, Yazd - Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd , Salehi-Abargouei, Amin Nutrition and Food Security Research Center - Shahid Sadoughi University of Medical Sciences, Yazd - Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd , Raeisi-Dehkordi, Hamidreza Nutrition and Food Security Research Center - Shahid Sadoughi University of Medical Sciences, Yazd - Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd , Moghtaderi, Fatemeh Nutrition and Food Security Research Center - Shahid Sadoughi University of Medical Sciences, Yazd - Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd , Zimorovat, Alireza Nutrition and Food Security Research Center - Shahid Sadoughi University of Medical Sciences, Yazd - Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd , Yasini Ardakani, Ali Department of Food Science and Technology - Islamic Azad University, Yazd , Salehi-Abargouei, Amin Nutrition and Food Security Research Center - Shahid Sadoughi University of Medical Sciences, Yazd - Department of Nutrition - School of Public Health - Shahid Sadoughi University of Medical Sciences, Yazd
Abstract :
Introduction: Cholesteryl ester transfer protein (CETP) is a key regulating enzyme in the lipid metabolism pathway, and its gene polymorphism may be a candidate for modulating the metabolic responses to dietary intervention. We thus examined whether the effects of the CETP TaqIB
polymorphism on metabolic profiles were modified by dietary plant oils.
Methods: This is a retrospective analysis of data collected during a randomized triple-blind crossover
trial. A total of 95 patients with type 2 diabetes and 73 non-diabetes individuals completed a 9-week
of the intake of sesame, canola and sesame-canola oils. Blood samples were collected at the beginning
and at the end of each intervention period for biochemical analysis. Genotyping was done using the
polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
Results: In diabetes patients, B1B1 homozygotes of the CETP TaqIB polymorphism compared with
B2 carriers (B1B2 + B2B2) had significantly lower diastolic blood pressure, apoB and apoB: apoA-1,
and higher Lp(a) after the intake of sesame-canola oil, as well as lower insulin and HOMA-IR after
the intake of sesame oil. There was also a significant effect of genotype on adjusted changes of apoB,
apoB: apoA-1, insulin, HOMA-IR and QUICKI. A significant genotype-dietary oils combined effects
were observed for diastolic blood pressure, and LDL: HDL, TC: HDL and TG: HDL ratios in diabetes
patients. No independent or combined effects of dietary oils and genotypes on outcomes were found
in healthy people.
Conclusion: There was a modulatory effect of the CETP TaqIB polymorphism on some metabolic traits
in response to plant oils in patients with diabetes. Taken together, the intake of sesame-canola and
canola oils showed more favorable effects in diabetes patients with B1B1 genotype. Future investigations are needed to confirm these results.
Keywords :
Cholesterol Ester Transfer Proteins , Diabetes Mellitus , Sesame Oil , Canola Oil , Sesame-Canola Oil , Polymorphism
