Author/Authors :
Salehi, Bahare Noncommunicable Diseases Research Center - Bam University of Medical Sciences, Bam, Iran. , Mishra, Abhay P. Department of Pharmaceutical Chemistry - H. N. B. Garhwal (A Central) University - Srinagar Garhwal, 246174, Uttarakhand, India , Nigam, Manisha Department of Biochemistry - H. N. B. Garhwal (A Central) University - Srinagar Garhwal, 246174, Uttarakhand, India , Kobarfard, Farzad Phytochemistry Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Javed, Zeeshan Office for Research innovation and commercialization (ORIC) Lahore garrison University - sector-c phase VI, DHA, Lahore Pakistan , Khan, Khushbakht Atta-ur-Rahman School of Appli,ed Biosciences (ASAB) - National University of Sciences and Technology (NUST) - Islamabad 44000, Pakistan , Ashfaq, Hafiz Ahsan Department of Clinical Biochemistry - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Ahmad, Toqeer Department of Nutrition and Dietetics - Faculty of Pharmacy - and Centre for Healthy Living - University of Concepcion - Concepcion 4070386, Chile , Pezzani, Raffaele OU Endocrinology - Dept. Medicine (DIMED) - University of Padova, via Ospedale 105, Padova 35128, Italy , Martorell, Miquel Department of Nutrition and Dietetics - Faculty of Pharmacy - and Centre for Healthy Living, University of Concepcion , Cho, William C. Department of Clinical Oncology - Queen Elizabeth Hospital - 30 Gascoigne Road, Hong Kong, China , Ayatollah, Abdulmajid Phytochemistry Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Sharifi-Rad, Javad Phytochemistry Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Drug development is a key point in the research of new therapeutic treatments for increasing maximum drug loading and prolonged drug effect. Encapsulation of drugs into multivesicular liposomes (DepoFoam) is a nanotechnology that allow deliver of the active constituent at a sufficient concentration during the entire treatment period. This guarantees the reduction of drug administration frequency, a very important factor in a prolonged treatment. Currently, diverse DepoFoam drugs are approved for clinical use against neurological diseases and for post-surgical pain management while other are under development for reducing surgical bleeding and for post-surgical analgesia. Also, on pre-clinical trials on cancer DepoFoam can improve bioavailability and stability of the drug molecules minimizing side effects by site-specific targeted delivery. In the current work, available literature on structure, preparation and pharmacokinetics of DepoFoam are reviewed. Moreover, we investigated approved DepoFoam formulations and preclinical studies with this nanotechnology.
