Title of article :
The Effects of Hydro-alcoholic Extracts of Allium sativum L. and Orchismaculata L. on Spermatogenesis Index and Testosterone Level in Cyclophosphamide-treated Rats
Author/Authors :
Sadeghzadeh, Firouze Traditional and Complementary Medicine Research Center - Arak University of Medical University , Sadeghzadeh, Azizieh Traditional and Complementary Medicine Research Center - Arak University of Medical University , Changizi-Ashtiyani, Saeed Department of Physiology - School of Paramedical Sciences - Arak University of Medical Sciences , Alimoradian, Abass Traditional and Complementary Medicine Research Center - Arak University of Medical University , Mashayekhei, Mehry Assistant Professor - Department of Endocrinology and Female Infertility - Reproductive Biomedicine Research Center - Royan Institute, Tehran , Zarei, Ali Assistant Professor - Department of Physiology - Shiraz University of Medical University , Jalali-Mashayekhi, Farideh Assistant Professor - Traditional and Complementary Medicine Research Center - Arak University of Medical University
Abstract :
One of the most common side effects of cyclophosphamide (CP) is oligospermatozoa, azoospermia and elimination of spermatogenic cycles. This study was done to
find the efficacy of simultaneous consumption of garlic (AlliumsativumL.) and orchid
(Orchismaculata L.) hydroalcoholic extracts on spermatogenesis and sex hormones in rats treated with CP.
Forty-two male rats were divided into the six groups: control, sham, CP
(5 mg/kg), garlic (10 mg/kg) + CP, orchid (40 mg/kg) + CP, garlic+ orchid + CP. All of the
agents were administered through oral gavage for 28 days.
The number of sperms increased in garlic+ CP and orchid+ CP groups. The
percentage of sperm forward motility increased in groups receiving garlic, orchid, and garlic
+orchid compared with the group that received only CP.
Antioxidant total capacity and testosterone level showed significant increases in garlic+
orchid, garlic and orchid groups respectively compared with the group that received only CP
(P<0.05). Also, the tissue and serum malondialdehyde levels reduced in the group received
garlic +orchid compared with the group that received only CP.
Garlic and orchid could increase the number and the motility of sperms,
index of sertoli cell, antioxidant capacity and serum testosterone level.
Keywords :
Infertility , Garlic , Orchid , Cyclophosphamide , Spermatogenesis
Journal title :
Journal of Kerman University of Medical Sciences (JKMU)
