Title of article
New Emerging SARS-CoV-2 Virus; Structure, Function, and Bioinformatics Analysis
Author/Authors
Hosseinpour, Milad Student Research Committee - Iran University of Medical Sciences (IUMS), Tehran, Iran , Safari Dizaj, Reza Department of Medical Genetics and Molecular Biology - Faculty of Medicine - Iran University of Medical Sciences (IUMS), Tehran, Iran , Sohrabi, Ehsan Department of Medical Genetics and Molecular Biology - Faculty of Medicine - Iran University of Medical Sciences (IUMS), Tehran, Iran , Abbasi Dezfouli, Saba Department of Biotechnology - School of Advanced Science and Technology - Tehran Medical Sciences, Islamic Azad University, Tehran, Iran , Khorasanian, Reihane Department of Medical Genetics and Molecular Biology - Faculty of Medicine - Iran University of Medical Sciences (IUMS), Tehran, Iran , Zekri, Ali Physiology Research Center - Faculty of Medicine - Iran University of Medical Sciences (IUMS), Tehran, Iran
Pages
11
From page
1
To page
11
Abstract
The novel coronavirus, known as a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is a single-stranded RNA virus, from which structural and some accessory proteins are encoded. It seems that this newly emerged virus uses the ACE2 receptor to enter the cells in the human body. SARS-CoV-2 undergoes an intense immunological pressure in humans, and this generates mutations to bypass the immune system. Some mutations have been detected in this virus genome, which can induce a change in viral potency. By performing pathway enrichment analysis over those genes and identifying relevant protein-protein interactions (PPIs), we were able to list essential pathways affected in infected cells. In this review, we mainly discuss genetic, intracellular mechanisms, diagnosis and feasible therapeutic targets of this novel coronavirus.
Keywords
Genomic Structural Variation , SARS-CoV-2 , Signal Transduction , Mutation
Journal title
Journal of Pediatric Nephrology
Serial Year
2020
Record number
2520249
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