Title of article :
Evaluation of Relationship between Streptococcus mutans, Dental Caries and IL-1α and IL-6
Author/Authors :
Eslami, Hossein Assistant Professor - Department of Oral Medicine - Faculty of Dentistry - Tabriz University of Medical Sciences , Pouralibaba, Firoz Assistant Professor - Department of Oral Medicine - Faculty of Dentistry - Tabriz University of Medical Sciences , Rezaii Sepas, Roya Private Practice, Tabriz , Zarandi, Ali Assistant Professor - Department of Periodontics - Faculty of Dentistry - Tabriz University of Medical Sciences
Abstract :
Background and aims. Streptococcus mutans is an important species in oral microflora and its components have been found to stimulate production of proinflammatory cytokines in dental caries. The aim of this study was to evaluate proin-flammatory cytokines (IL-1α and IL-6) in patients with S. mutans.
Materials and methods. Seventy samples were selected during pulpectomy and investigated for the presence of IL-1α and IL-6 by ELISA. The results were analyzed by t-test (α = 0.05).
Results. The results showed higher mean concentrations of IL-6 and IL-1a in inflamed pulpal tissues in subjects with den-tal caries associated with S. mutans, compared with intact pulpal tissue samples; these higher means were statistically sig-nificant in all cases (P<0.05).
Conclusion. The results of this study suggested relations between the production of IL1-a and IL-6 in dental caries caused by S. mutans.
Keywords :
Dental caries , interleukin-6 , interleukin-1α , inflammation , Streptococcus mutans
Journal title :
Journal of Advanced Periodontology and Implant Dentistry
