Author/Authors :
Salehi-Sahlabadi, Ammar Student Research Committee - Department of Clinical Nutrition and Dietetics - Faculty of Nutrition and Food Technology, National Nutrition and Food Technology - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Mokari, Amin Department of Community Nutrition - Faculty of Nutrition and Food Technology - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Elhamkia, Maryam School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran, Iran , Farahmand, Fariba School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran, Iran , Jabbari, Masoumeh Department of Community Nutrition - Faculty of Nutrition and Food Technology - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Hekmatdoost, Azita Department of Clinical Nutrition and Dietetics - Faculty of Nutrition and Food Technology - National Nutrition and Food Technology - Research Institute - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Background: Dietary total antioxidant capacity (DTAC) has been proposed as a tool for assessing
the intake of antioxidants. This study aimed to assess whether a relationship exists between dietary
total antioxidant capacity (TAC) and the odds of NAFLD.
Study design: A case-control study.
Methods: In this age‐and sex‐matched case‐control study in 2019, patients with NAFLD and
healthy controls were recruited from a hospital clinic. All participants completed a validated 168‐
item food frequency questionnaire, the results of which were subsequently used to generate dietary
TAC. Oxygen radical absorbance capacity values were used to calculate dietary TAC.
Results: Altogether, 225 patients with NAFLD and 450 healthy controls were enrolled. Participants
with NAFLD had a higher mean weight, BMI, energy (P<0.050), and lower physical activity and
DTAC scores (P<0.050) than the control group. In an adjusted model, participants who were in the
highest quartile of dietary TAC had a lower risk of NAFLD (odds ratio 0.78, 95% CI: 0.67, 0.91).
Conclusion: A high DTAC was related to a decreased risk of NAFLD. Suggest the intake of a diet
with high antioxidant capacity is significant at preventing NAFLD. Increasingly itemized
investigations in design of randomized control trials require to reveal more insight into these results.
