Author/Authors :
Salehi, Hassan Infectious Diseases and Tropical Medicine Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Salehi, Marzieh Department of Infectious Diseases - Medical School - Isfahan University of Medical Sciences, Isfahan, Iran , Kalbasi, Nader Department of Oral and Facial Pathology - Dentistry Faculty - Khoraskan University, Isfahan, Iran , Salehi, Maryam Dentistry Student Research Center - Dentistry School - Isfahan University of Medical Sciences, Isfahan, Iran , Sharifian, Jalil Oral Surgery Department - Dentistry School - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Salehi, Mohammad Mahdi Dentistry Student Research Center - Dentistry School - Isfahan University of Medical Sciences, Isfahan, Iran
Abstract :
Background: Conventional hepatitis B virus vaccination fails to achieve efficient protection in about 5%–10% of the world population.
Different factors influence the immunogenicity of hepatitis B vaccine. This study aimed to evaluate these factors in health‑care
workers. Materials and Methods: This was a descriptive study which was implemented among 140 of medical and dental staff
working as health‑care workers who were low responder after vaccination entered the study. Results: Age (>40 years), weight (body
mass index >25), immunodeficiency diseases, (primary immune deficiency and immunosuppressant drugs), diabetes mellitus, and
smoking were the important factors. Conclusion: In the high‑risk group of hepatitis B disease, the risk factors of immunogenicity
must be evaluated at vaccination and check titers of antibody after vaccination.
