Author/Authors :
Rodrigues Junior, Luiz Fernando Laboratory of Clinical Research on Chagas Disease - Evandro Chagas National Institute of Infectious Diseases - Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil , Sardinha Mendes, Fernanda de Souza Nogueira Laboratory of Clinical Research on Chagas Disease - Evandro Chagas National Institute of Infectious Diseases - Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil , Pinto, Vivian Liane Mattos Laboratory of Clinical Research on Chagas Disease - Evandro Chagas National Institute of Infectious Diseases - Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil , da Silva, Paula Simplicio Laboratory of Clinical Research on Chagas Disease - Evandro Chagas National Institute of Infectious Diseases - Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil , da Silva, Gilberto Marcelo Sperandio Laboratory of Clinical Research on Chagas Disease - Evandro Chagas National Institute of Infectious Diseases - Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil , Pinheiro, Roberta Olmo Leprosy Laboratory - Oswaldo Cruz Institute - Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil , de Sousa, Andréa Silvestre Laboratory of Clinical Research on Chagas Disease - Evandro Chagas National Institute of Infectious Diseases - Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil , Mediano, Mauro Felippe Felix Laboratory of Clinical Research on Chagas Disease - Evandro Chagas National Institute of Infectious Diseases - Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil
Abstract :
Background: Cardiac rehabilitation exerts anti‑inflammatory effect on several cardiovascular diseases; however, these effects were not
described for Chagas cardiomyopathy, which is associated with pro‑inflammatory imbalance. Materials and Methods: Ten patients with
severe Chagas cardiomyopathy performed 8 months of exercise training in a cardiac rehabilitation program. Interleukin‑1 beta (IL‑1β),
IL‑8, IL‑10, interferon gamma (IF‑γ), tumor necrosis factor alpha (TNF‑α), and monocyte chemoattractant protein‑1 (MCP‑1) serum
levels were measured using enzyme‑linked immunosorbent assay at baseline, 4, and 8 months. The influence of exercise on cytokine levels
was evaluated using the one‑way analysis of variance for repeated measurements, with Bonferroni posttest for multiple comparisons.
Results: Levels of pro‑inflammatory (TNF‑α, IL‑1β, IL‑8, IF‑γ, and (MCP‑1) and anti‑inflammatory (IL‑10) cytokines did not vary
significantly during the observation period. Conclusion: Exercise may benefit patients with severe Chagas cardiomyopathy by curbing
the production of pro‑inflammatory cytokines in this disease characterized by a continuous state of inflammation.
Keywords :
heart failure , cytokines , Chagas cardiomyopathy , Cardiac rehabilitation
