Author/Authors :
Kalantar, Enayatollah Dietary Supplements and Probiotics Research Center - Alborz University of Medical Sciences, Karaj, Iran , Gharavi, Mohammad Javad Alborz University of Medical Sciences, Karaj, Iran , Oshaghi, Mojgan Department of Microbiology and Immunology - School of Paramedical Sciences - Iran University of Medical Sciences, Tehran, Iran , Gharegozlou, Behnaz Department of Microbiology and Immunology - School of Paramedical Sciences - Iran University of Medical Sciences, Tehran, Iran , Mohammadi, Sara Alborz University of Medical Sciences, Karaj, Iran , Heshmat, Ramin Epidemiology Department - Chronic Diseases Research Center -Endocrinology and Metabolism Population Sciences Institute - Tehran University of Medical Sciences, Iran , Ghaffari Hiseini, Shervin Infectious Diseases and Tropical Medicine Research Center - Isfahan University of Medical Sciences, Iran , Motlagh, Mohammad Esmaeil Department of Pediatrics - Ahvaz Jundishapur University of Medical Sciences, Iran , Qorbani, Mostafa Non-communicable of Disease Research Center - Alborz University of Medical Sciences, Karaj, Iran , Kelishadi, Roya Department of Pediatrics - Child Growth and Development Research Center - Research Institute for Primordial Prevention of Non-communicable Disease - Isfahan University of Medical Sciences, Iran
Abstract :
Background: Helicobacter pylori (H.pylori) is a common bacterial infection, with considerably high
morbidity and mortality worldwide. This bacterium represents a key factor in the etiology of various
chronic infections ranging from gastritis, peptic ulcer disease to gastric cancer; but the prevalence has
large variations in different communities. The aim of this study was to estimate the prevalence H.
pylori infection in a nationally representative sample of Iranian adolescents.
Materials and Methods: In this cross-sectional study, serum samples of 882 Iranian adolescents, aged
10-18 years, were examined for seroprevalence of H.pylori. They were randomly selected from the
samples obtained in the third survey of a national surveillance program (the CASPIAN III study).
Seroprevalence of H. pylori was examined by detection of H. pylori immunoglobulin A (IgA),
immunoglobulin G (IgG) and immunoglobulin M (IgM) in sera by using Enzyme Linked
Immunosorbant Assay (ELISA).
Results: The study participants had a mean age of 14.82 + 2.77 years. Overall, 51.7% of students
were boys and 61.52% were urban residents. The H. pylori IGM and IGA seropositivity had no
significant association with demographic characteristics (p>0.05). The H. pylori IgG seropositivity
were significantly different in boys and girls (69.7%, 95% confidence interval [CI] = 66.7-72.7 vs.
76.3%, 95%CI= 73.5-79. 1, respectively, P=0.03).
Conclusion: The seroprevalence of H. pylori IgG in Iranian adolescents is high, and girls had greater
risk of H. pylori IgG seropositivity compared to boys. Preventive strategies and health education are
recommended to reduce the prevalence of this infection in Iranian adolescent.
Keywords :
Adolescents , Helicobacter pylori , Iran , Seroprevalence
