Title of article :
Human Split-Thickness Skin Allograft from Brain-Dead Donors
Author/Authors :
Khodadadi, A Iranian Tissue Bank Research Center - Tehran University of Medical Sciences , Olang, O Faculty of Medicine - Shahid Beheshti University of Medical Sciences , Makhlough, A i Molecular and Biology Research Center - Mazandaran University of Medical Sciences , Nozary Heshmati, B Iranian Tissue Bank Research Center - Tehran University of Medical Sciences , Azmoudeh Ardalan, F Iranian Tissue Bank Research Center - Tehran University of Medical Sciences , .Tavakol, SA Iranian Tissue Bank Research Center - Tehran University of Medical Sciences
Abstract :
Background: Looking for an appropriate skin substitute for temporary and permanent coverage of wounds remains one of the main obstacles of medical researchers.
Objective: To investigate the rate of inflammation, symbiosis, and survival of grafted allograft skin from brain-dead donors (BDDs) in rabbits.
Methods: After receiving negative serologic tests of BDDs, we prepared partial thickness skin grafts. They were then used in treating wounds of 5 rabbits in comparison with split-thickness skins taken from cardiac dead donors.
Results: On histopathological examinations, we found no difference between the skins. All samples were separated from the baseline in 15–20 days.
Conclusion: Gamma-irradiated freeze-dried human split-thickness skin taken from BDDs is safe and can be used for the treatment of deep skin burns.
Keywords :
Inflammation , Symbiosis , Biological dressings , Graft rejection , Graft , Survival
Journal title :
International Journal of Organ Transplantation Medicine
