Author/Authors :
Abdolrahimzadeh, Solmaz Ophthalmology Unit - Neurosciences, Mental Health and Sensory Organs Department - St. Andrea Hospital - Sapienza University of Rome, Rome, Italy , Fameli, Valeria Ophthalmology Unit - Department of Sense Organs - Sapienza University of Rome, Rome, Italy , Di Tizio, Federico Ophthalmology Unit - Neurosciences, Mental Health and Sensory Organs Department - St. Andrea Hospital - Sapienza University of Rome, Rome, Italy , Di Staso, Federico Ophthalmology Unit - Neurosciences, Mental Health and Sensory Organs Department - St. Andrea Hospital - Sapienza University of Rome, Rome, Italy , Fenicia, Vito Ophthalmology Unit - Neurosciences, Mental Health and Sensory Organs Department - St. Andrea Hospital - Sapienza University of Rome, Rome, Italy , Scuderi, Gianluca Ophthalmology Unit - Neurosciences, Mental Health and Sensory Organs Department - St. Andrea Hospital - Sapienza University of Rome, Rome, Italy
Abstract :
Purpose: To report the effect of topical bromfenac, a non-steroidal anti‑inflammatory drug (NSAID), in a case of neovascular age‑related
macular degeneration (AMD).
Methods: An 85‑year‑old woman presented with a complaint of visual acuity reduction in the right eye. Comprehensive ophthalmological
examination and retinal imaging were performed.
Results: Best corrected visual acuity was 2/100. Fundus examination showed reticular pseudodrusen and a small hemorrhage in the fovea.
Fluorescein angiography showed an active neovascular membrane. Spectral-domain optical coherence tomography (SD‑OCT) confirmed
diagnosis and revealed subretinal and intraretinal fluid. The patient refused recommended intravitreal anti‑vascular endothelial growth factor
treatment and received topical bromfenac 0.09% twice daily. Follow‑up with SD‑OCT showed subretinal followed by intraretinal fluid
reduction at 16 weeks after treatment.
Conclusion: Short‑term reduction of subretinal and intraretinal fluid was observed with topical bromfenac monotherapy in neovascular AMD.
Keywords :
Age‑related macular degeneration , Bromfenac , Intraretinal fluid , Spectral domain optical coherence tomography , Subretinal fluid
