Author/Authors :
Hormati, Ahmad Gastroenterology and Hepatology Diseases Research Center - Qom University of Medical Sciences, Qom, Iran , Jafari, Saeede Social Determinants of Health Research Center - Research Institute for Health Development - Kurdistan University of Medical Sciences, Sanandaj, Iran , Jabbari, Amir Department of Internal Medicine - Faculty of Medicine - Qom University of Medical Sciences, Qom, Iran , Pezeshki Modares, Mahdi Gastroenterology and Hepatology Diseases Research Center - Qom University of Medical Sciences, Qom, Iran , Afifian, Mahboubeh Health Information Technology - Tehran University of Medical Sciences, Tehran, Iran , Abasi, Ahmad Department of Internal Medicine - Faculty of Medicine - Qom University of Medical Sciences, Qom, Iran , Ahmadpour, Sajjad Gastroenterology and Hepatology Diseases Research Center - Qom University of Medical Sciences, Qom, Iran , Sharifi, Ali Reza Student Research Committee - Qom university of Medical Sciences, Qom, Iran
Abstract :
BACKGROUND
Cholangiocarcinoma is the second most common malignant liver cancer. Its early
diagnosis plays an important role in the success of treatment. The aim of this study was
to compare the use of cold forceps biopsy without cholangioscopy with brush cytology
in the diagnosis of cholangiocarcinoma.
METHODS
In this prospective study, we enrolled 19 patients. Endoscopic retrograde cholangiopancreatography
(ERCP) was performed for all individuals. Sampling was performed
from the narrowing site using the brush method. Then, a cold forceps biopsy was
performed under fluoroscopy.
RESULTS
The mean age of the patients was 63.31 ± 11.12 years and most of them were men
(63.16 %). The brush cytology and the cold forceps biopsy diagnosed 31.85% and
68.42% of the samples as cholangiocarcinoma, respectively. According to the McNemar
test, there was a statistically significant difference between the diagnostic results of the
brush cytology and cold forceps biopsy. So that more cholangiocarcinoma cases were
diagnosed using forceps biopsy (p = 0.016). No complications such as perforation, bleeding,
cholangitis, and leakage were reported during the cold forceps procedure.
CONCLUSION
Cold forceps biopsy under fluoroscopy is better than cytology brush in the diagnosis
of proximal cholangiocarcinoma. It is recommended to be used as a low-cost alternative
in cases where cholangioscopy is not available.
Keywords :
Cholangiocarcinoma , Cytology , Biopsy , Diagnosis
