Author/Authors :
Qasempour, Younes Student Research Committee - School of Allied Medicine - Kerman University of Medical Sciences, Kerman, Iran , Mohammadi, Amirsalar Student Research Committee - School of Allied Medicine - Kerman University of Medical Sciences, Kerman, Iran , Rezaei, Mostafa Student Research Committee - School of Allied Medicine - Kerman University of Medical Sciences, Kerman, Iran , Pourya zadanpanah, Parisa Student Research Committee - School of Allied Medicine - Kerman University of Medical Sciences, Kerman, Iran , Ziaddini, Fatemeh Student Research Committee - School of Allied Medicine - Kerman University of Medical Sciences, Kerman, Iran , Borbori, Alma Student Research Committee - School of Allied Medicine - Kerman University of Medical Sciences, Kerman, Iran , Shiri, Isaac Division of Nuclear Medicine and Molecular Imaging - Geneva University Hospital, Geneva, Switzerland , Hajianfar, Ghasem Department of Biomedical and Health Informatics, Rajaiee Cardiovascular Medical and Research Cente - Iran University of Medical Science, Tehran, Iran , Janati, Azam Department of Medical Biotechnology - School of Paramedical Sciences - Qazvin University of Medical Sciences, Qazvin, Iran , Ghasemirad, Sareh Department of Emergency Medicine - School of Medicine - Kerman University of Medical Sciences, Kerman, Iran , Abdollahi, Hamid Student Research Committee - School of Allied Medicine - Kerman University of Medical Sciences, Kerman, Iran
Abstract :
Background: Feature reproducibility is a critical issue in quantitative radiomic studies. The aim
of this study is to assess how radiographic radiomic textures behave against changes in phantom
materials, their arrangements, and focal spot size. Method: A phantom with detachable parts was
made using wood, sponge, Plexiglas, and rubber. Each material had 1 cm thickness and was imaged
for consecutive time. The phantom also was imaged by change in the arrangement of its materials.
Imaging was done with two focal spot sizes including 0.6 and 1.2 mm. All images were acquired
with a digital radiography machine. Several texture features were extracted from the same size
region of interest in all images. To assess reproducibility, coefficient of variation (COV), intraclass
correlation coefficient (ICC), and Bland–Altman tests were used. Results: Results show that 59%,
50%, and 4.5% of all features are most reproducible (COV ≤5%) against change in focal spot size,
material arrangements, and phantom’s materials, respectively. Results on Bland–Altman analysis
showed that there is just a nonreproducible feature against change in the focal spot size. On the ICC
results, we observed that the ICCs for more features are >0.90 and there were few features with ICC
lower than 0.90. Conclusion: We showed that radiomic textures are vulnerable against changes in
materials, arrangement, and different focal spot sizes. These results suggest that a careful analysis of
the effects of these parameters is essential before any radiomic clinical application.
Keywords :
Arrangement , focal spot , materials , radiomic textures , reproducibility
