Title of article :
The Measurement of Thyroid Absorbed dose by Gafchromic™ EBT2 Film and Changes in Thyroid Hormone Levels Following Radiotherapy in Patients with Breast Cancer
Author/Authors :
Ansari, Leyla Department of Radiation Sciences - Faculty of Paramedicine - Yasuj University of Medical Science, Yasuj , Nasiri, Neda Department of Medical Radiation Engineering - Science and Research Branch, Islamic Azad University , Aminolroayaei, Fahimeh Department of Medical Physics and Radiology - School of Allied Medicine - Kashan University of Medical Sciences, Kashan , Ghazikhanlou Sani, Karim Department of Radiology - Paramedical School - Hamadan University of Medical Sciences, Hamadan , Dorri‑Giv, Masoumeh Department of Paramedical - Shahid Beheshti University of Medical Science, Tehran , Abedi‑Firouzjah, Razzagh Department of Medical Physics Radiobiology and Radiation Protection - School of Medicine - Babol University of Medical Sciences, Babol, Iran , Sardari, Dariush Department of Medical Radiation Engineering - Science and Research Branch, Islamic Azad University
Abstract :
Background: Radiotherapy is a main method for the treatment of breast cancer. This study aimed
to measure the absorbed dose of thyroid gland using Gafchromic EBT2 film during breast cancer
radiotherapy. In addition, the relationship between the absorbed dose and thyroid hormone levels was
evaluated. Methods: Forty‑six breast cancer patients, with the age ranged between 25 and 35 years,
undergoing external radiotherapy were studied. The patients were treated with 6 and 18 MV X‑ray
beams, and the absorbed thyroid dose was measured by EBT2 film. Thyroid hormone levels,
thyroid‑stimulating hormone (TSH), triiodothyronine (T3), and thyroxin (T4), were measured before
and after the radiotherapy. Pearson’s, Spearman’s, and Chi‑square tests were performed to evaluate
the correlation between the thyroid dose and hormone levels. Results: The mean thyroid dose
was 26 ± 9.45 cGy with the range of 7.85–48.35 cGy. There were not any significant differences
at thyroid hormone levels between preradiotherapy and postradiotherapy (P > 0.05). There was
a significant relationship between increased thyroid absorbed dose and changes in TSH and T4
levels (P < 0.05), but it was not significant in T3 level (P = 0.1). Conclusion: Regarding the results,
the thyroid absorbed dose can have an effect on its function. Therefore, the thyroid gland should be
considered as an organ at risk in breast cancer radiotherapy.
Keywords :
Breast cancer , Gafchromic film , radiotherapy , thyroid gland
Journal title :
Journal of Medical Signals and Sensors (JMSS)
