Title of article
Comparison of the effects of sertraline and L-carnitine on intradialytic hypotension; a double blind clinical trial
Author/Authors
Jamshidi, Sanaz Qazvin University of Medical Sciences, Qazvin, Iran , Hajian, Sepideh Department of Nephrology - Velayat Hospital - Qazvin University of Medical Sciences, Qazvin, Iran , Rastgoo, Nafiseh Qazvin University of Medical Sciences, Qazvin, Iran , Mohammadi, Navid Department of Family and Community Medicine - School of Medicine - Qazvin University of Medical Sciences, Qazvin, Iran
Pages
7
From page
1
To page
7
Abstract
Introduction: Although some studies have reported the positive effect of sertraline and L-carnitine on intradialytic hypotension (IDH), a common complication of dialysis, however the results are controversial.
Objectives: The aim of this study was to compare the effects of sertraline and L-carnitine on blood pressure in patients with chronic renal failure who were undergoing dialysis.
Patients and Methods: This double-blind clinical trial was conducted on 32 hemodialysis patients who suffered from IDH in more than 50% of dialysis sessions. Patients were randomly divided into two groups of sertraline (50 mg daily) and L-carnitine (1000 mg daily), with 16 patients in each group. Duration of treatment was four weeks, then patients were followed up for additional three weeks. The changes in patients’ blood pressure were monitored in each group and the results compared between the two groups.
Keywords
Hemodialysis , Intradialytic hypotension , Sertraline , L-Carnitine , Chronic kidney disease , End-stage kidney disease
Journal title
Journal of Renal Injury Prevention
Serial Year
2020
Record number
2523363
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