Title of article
COVID-19 interactions with angiotensin-converting enzyme 2 (ACE2) and the kinin system; looking at a potential treatment
Author/Authors
Tolouian, Ramin Division of Nephrology - College of Medicine - University of Arizona, Tucson, AZ, USA , Zununi Vahed, Sepideh Kidney Research Center - University of Medical Sciences, Tabriz, Iran , Ghiyasvand, Shahram Kidney Research Center - University of Medical Sciences, Tabriz, Iran , Tolouian, Audrey School of Nursing - The University of Texas at El Paso, TX, USA , Ardalan, Mohammadreza Kidney Research Center - University of Medical Sciences, Tabriz, Iran
Pages
4
From page
1
To page
4
Abstract
The novel coronavirus disease 2019 (COVID-19) is a rapidly expanding infection around the world. The world Health Organization (WHO) in March 2020 announced the Coronavirus pandemic. This infection causes many deaths on daily basis. Therapeutic options are currently limited. It is revealed that COVID-19 binds to human angiotensin-converting enzyme 2 (ACE2) to enter the host cells. One of the activities of ACE2 is hydrolyzing the active bradykinin metabolite [des-Arg973] BK (DABK). A decreased activity or reducing expression of ACE2 by the virus impairs the inactivation of DABK. This enhances its signaling through the bradykinin B1 receptor (BKB1R) and could lead to fluid extravasation and leukocyte recruitment to the lung. Targeting the bradykinin system by either blocking the bradykinin production or blocking bradykinin receptors may open a new potential therapeutic window for the treatment of COVID-19 induced acute respiratory distress syndrome (ARDS) particularly before patients enter the irreversible stages.
Keywords
COVID-19 , SARS-CoV , Bradykinin , Lung injury , ACE2 , Coronavirus , Acute respiratory distress syndrome , Angiotensin converting enzyme2
Journal title
Journal of Renal Injury Prevention
Serial Year
2020
Record number
2523618
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