Title of article :
Green synthesis of isoquinoline derivatives using multicomponent reactions of amides
Author/Authors :
Sharifi, Samanehsadat Department of Chemistry - Sistan and Balochestan University, Zahedan, Iran , Khandanb, Samira bDepartment of Chemistry - Islamic Azad University Science and research Branch,Tehran, Iran
Abstract :
Abstract: Isoquinoline that is produced from the reaction of phthalaldehyde and methyl amine reacts smoothly with dialkyl acetylenedicarboxylate in the presence of amides to produce isoquinoline derivatives. The advantages of this procedure than to reported methods are short time of reaction, high yields of product, easy separation of product, clean mixture of reaction and green media for performing reaction.
Keywords :
Four-component reactions , Isoquinoline , Amide
Journal title :
Iranian Journal of Organic Chemistry
