Author/Authors :
Abolghasemi, Sara Clinical Tuberculosis and Epidemiology Research Center - National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences, Tehran , Sharif-Kashani, Babak Chronic Respiratory Disease Research Center - NRITLD - Shahid Beheshti University of Medical Sciences, Tehran , Naghashzadeh, Farah Chronic Respiratory Disease Research Center - NRITLD - Shahid Beheshti University of Medical Sciences, Tehran , Marjani, Majid Clinical Tuberculosis and Epidemiology Research Center - National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences, Tehran , Moniri, Afshin Clinical Tuberculosis and Epidemiology Research Center - National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences, Tehran , Doroudinia, Atousa Clinical Tuberculosis and Epidemiology Research Center - National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences, Tehran , Tabarsi, Payam Clinical Tuberculosis and Epidemiology Research Center - National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences, Tehran
Abstract :
Pneumocystis pneumonia (PCP) is a common opportunistic infection in
immunocompromised patients. In general, clinical response to therapy with
cotrimoxazole is excellent. However, therapy may be limited by side effects or
treatment failure. We present a case of PCP in a 35-year-old male patient with
history of heart transplantation and renal failure who was admitted with a 10-
day history of fever, nonproductive cough and elevated level of creatinine with
a diagnosis of PCP confirmed by chest radiography and in bronchoalveolar
lavage specimens. He was treated with trimethoprim-sulphamethoxazole
(SMZ/TMP) and primaquine but treatment was completed with reduced
dosage of cotrimoxazole, primaquine and with the addition of caspofungin.
This therapy was effective and without any adverse effects in a patient with
elevated level of creatinine.
