Author/Authors :
Pourostadi, Mahya Hematology and Oncology Research Center - Tabriz University of Medical Sciences, Tabriz , Rashedi, Jalil Tuberculosis and Lung Diseases Research Center and Department of Laboratory Science - Faculty of Paramedicine - Tabriz University of Medical Sciences , Mahdavi Poor, Behroz Department of Laboratory Science - Faculty of Paramedicine - Tabriz University of Medical Sciences, Tabriz - and Department of Medical Parasitology - School of Medical Sciences - Tarbiat Modares University, Tehran , Samadi Kafil, Hossein Drug Applied Research Center - Tabriz University of Medical Sciences , Kazemi, Abdolhassan Infectious and Tropical Diseases Research Center - Tabriz University of Medical Sciences , Ahmadpour, Ehsan Department of Parasitology - Faculty of Medicine - Tabriz University of Medical Sciences , Asgharzadeh, Mohammad Biotechnology Research Center - Department of Laboratory Science - Faculty of Paramedicine - Tabriz University of Medical Sciences
Abstract :
Background: Tuberculosis (TB) is a public health problem in developing
countries and yet the numbers of people with the disease are abundant. Early
detection of transmission sources and effective treatment of the cases is
essential to control the disease which will be possible by application of
molecular epidemiology approaches. Studies conducted based on
Mycobacterial Interspersed Repetitive Units-Variable Number of Tandem
Repeats (MIRU-VNTR) method in Muslim Middle East countries were
evaluated to determine their role in TB control.
Materials and Methods: All studies from January 2005 to April 2016 were
systematically reviewed in four electronic databases and finally 16 articles were
found eligible to be included in this study. The mean clustering rate was
determined as 44% and the recent transmission rate was 12.3 to 78.8% with
average of 33%. Results: The results showed that both reactivation and recent transmission
were important in developing new cases of TB in Middle East countries; but,
reactivation plays a more critical role.
Conclusion: Regarding to ongoing war and immigration in the region along
with the increasing of drug-resistant TB, in the case of improper supervision in
the future, the disease, especially drug- resistant TB, will be problematic.
Keywords :
Molecular epidemiology , MIRU-VNTR , tuberculosis , transmission , Middle East
