Author/Authors :
Mohammadpour, Hadiseh Dental Research Center - Dentistry Research Institute - Tehran University of Medical Sciences , Ziai, Ali Department of Pharmacology - School of Medicine - Shahid Beheshti University of Medical Sciences, Tehran , Sadr, Makan Virology Research Center - National Research Institutes of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences, Tehran , Rezaei, Mitra Virology Research Center - National Research Institutes of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences, Tehran , Marjani, Majid Clinical Tuberculosis and Epidemiology Research Center - NRITLD - Shahid Beheshti University of Medical Sciences, Tehran , Tabarsi, Payam Clinical Tuberculosis and Epidemiology Research Center - NRITLD - Shahid Beheshti University of Medical Sciences, Tehran
Abstract :
Coronaviruses (CoVs) are the largest group of positive-sense RNA viruses. By
increasing our understanding of the interactions between CoVs and the host
innate immune system, we can evaluate the development and persistence of
inflammation in the lungs and reduce the risk of CoV-induced lung
inflammation with a new group of genetic variants. Here, we aim to discuss
some recent changes in host cell factors that may be used by CoV to promote
the proliferation cycle. We also discuss different host cell signaling pathways
that can be considered in the host-pathogen interactions at the molecular level.
The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has created new challenges
for the cultural, economic, and health infrastructures. Therefore, it is important
that healthcare systems and physicians recognize a global integrated
framework for monitoring the progression of COVID-19 to develop targeted
therapies that can potentially save human lives.
Keywords :
Coronavirus , Host-pathogen interactions , Signaling pathways , COVID-19 , SARS-CoV-2
