Nanoporous metal-organic framework Cu2(BDC)2(DABCO) as an efficient heterogeneous catalyst for one-pot facile synthesis of 1,2,3-triazole derivatives in ethanol: Evaluating antimicrobial activity of the novel derivatives

Solvent-free ball-milling synthesized porous metal-organic framework Cu2(BDC)2(DABCO) (BDC: benzene-1,4-dicarboxylic acid, DABCO: 1,4-diazabicyclo[2.2.2]octane) proved to be a practical catalyst for facile and convenient synthesis of 1,2,3–triazole derivatives via multicomponent reaction of terminal alkynes, benzyl or alkyl halides, and sodium azide in ethanol. Avoidance of usage and handling of hazardous organic azides, using ethanol as an easy available solvent and catalyst simple preparation and its recycling makes this procedure truly a scale-up-able method. The high loading of copper ions in the catalyst causes efficient catalytic activity and hence its low weight usage in reaction. The catalyst was recycled and reused several times without significant loss of its activity. Furthermore, novel derivatives were examined to investigate their potential antimicrobial activity via microdilution method.