Author/Authors :
Golabgir Khademi , Khadijeh Dept. of Genetics - Faculty of Science - Shahid Chamran University of Ahvaz - Ahvaz, Iran , Foroughmand, Ali Mohammad Dept. of Genetics - Faculty of Science - Shahid Chamran University of Ahvaz - Ahvaz, Iran , Galehdari, Hamid Dept. of Genetics - Faculty of Science - Shahid Chamran University of Ahvaz - Ahvaz, Iran , Dinarvand , Parvaneh Dept. of Genetics - Faculty of Science - Shahid Chamran University of Ahvaz - Ahvaz, Iran , Shahbazi, Zahra Dept. of Genetics - Faculty of Science - Shahid Chamran University of Ahvaz - Ahvaz, Iran , Yazdankhah , Saied Dept. of Medicine - Jondi Shapour University of Medical Science - Ahvaz, Iran , Pourmahdi Borujeni , Mahdi Dept. of Food Hygiene - Faculty of Veterinary medicine - Shahid Chamran University of Ahvaz - Ahvaz, Iran
Abstract :
Coronary artery disease (CAD) is a multifactorial and heterogenic disease. Recently, genome-wide
association studies have reported that rs1333040 (C/T) and rs1004638 (A/T) single nucleotide polymorphisms
(SNPs) in the 9p21 locus have very strong association with CAD. This study aimed to examine these associations in
Southwest of Iran. Methods: Blood samples were collected from 200 CAD patients and 110 healthy individuals
with no CAD. The association of two SNPs with CAD was evaluated by PCR and restriction fragment length
polymorphism. Results: Chi-square test showed no association between rs1333040 SNP and CAD (X2: 4.66, df: 2,
P=0.09). Also, there was no association between rs1004638 SNP and CAD (X2: 0.27, df: 2, P=0.88). Conclusion: No
association was observed between rs1333040 and rs1004638 SNPs in the 9P21 region and CAD in Southwest of
Iran.
Keywords :
Genetic association study , Iran , Single nucleotide polymorphisms , Coronary artery disease
