Author/Authors :
Siadat, Davar Department of Mycobacteriology and Pulmonary Research - Pasteur Institute of Iran - Tehran, Iran , Afrough, Parviz Department of Mycobacteriology and Pulmonary Research - Pasteur Institute of Iran - Tehran, Iran , Rahimi-Jamnani, Fatemeh Department of Mycobacteriology and Pulmonary Research - Pasteur Institute of Iran - Tehran, Iran , Vaziri, Farzam Department of Mycobacteriology and Pulmonary Research - Pasteur Institute of Iran - Tehran, Iran , Behrouzi, Ava Department of Mycobacteriology and Pulmonary Research - Pasteur Institute of Iran - Tehran, Iran , Satarian, Fereshteh Department of Mycobacteriology and Pulmonary Research - Pasteur Institute of Iran - Tehran, Iran , Rahbar, Mohammad Department of Microbiology - Reference Health Laboratories Research Center - Ministry of Health and Medical Education - Tehran, Iran
Abstract :
Nonencapsulated, nontypeable Hemophilus influenzae (NTHi) remains an important cause of acute otitis and
respiratory diseases in children and adults. NTHi bacteria are one of the major causes of respiratory tract infections,
including acute otitis media, cystic fibrosis, and community-acquired pneumonia among children, especially in
developing countries. The bacteria can also cause chronic diseases such as chronic bronchitis and chronic
obstructive pulmonary disease in the lower respiratory tract of adults. Such bacteria express several outer
membrane proteins, some of which have been studied as candidates for vaccine development. Due to the lack of
effective vaccines as well as the spread and prevalence of NTHi worldwide, there is an urgent need to design and
develop effective vaccine candidates against these strains.
