Title of article :
Comparing Anti-hepatitis B Antibody Level in Iranian Obese or Overweight with Non-obese Cases
Author/Authors :
alavian, s.m. Middle East Liver Disease Center - Tehran, Iran , kabir, a. Minimally Invasive Surgery Research Center - Iran University of Medical Sciences - Tehran, Iran , pazouki, a. Minimally Invasive Surgery Research Center - Iran University of Medical Sciences - Tehran, Iran , jafari, m. Minimally Invasive Surgery Research Center - Iran University of Medical Sciences - Tehran, Iran , mokhber, s. Minimally Invasive Surgery Research Center - Iran University of Medical Sciences - Tehran, Iran , vaziri, m. Minimally Invasive Surgery Research Center - Iran University of Medical Sciences - Tehran, Iran
Abstract :
There is a controversy about the relation between anti-hepatitis B (anti-HBs) antibody level and
obesity. We designed this study to compare the vaccine efficacy in obese/overweight and non-obese cases.
Methods: In this cross-sectional study, 242 obese/overweight and 85 non-obese individuals were participated.
Cases were selected from a referral clinic for obesity and a referral hepatology clinic, both in Tehran, Iran.
Results: Obese cases had lower percentage of liver diseases (66.9% vs. 100%, P<0.001) but higher percentage of
hepatitis B vaccination history (74.9% vs. 51.2%, P<0.001). Median±inter-quartile range of anti-HBs titer in obese
cases was significantly lower than controls (48.5±194.5 vs. 100±557.6, P=0.012). Conclusion: The level of anti-HBs
surface antigen antibody’s titer in obese cases without liver disease is lower than control group. Therefore, a
suitable strategy is needed to overcome this problem, which can be the use of longer needles for vaccination.
Keywords :
Immunosuppressive agent , Liver diseases , Obesity , Hepatitis B vaccines
Journal title :
Iranian Biomedical Journal(IBJ)
