Title of article :
Interferon- Gamma- Inducible Guanosine Triphosphate Cyclohydrolase 1 (GTP-CH1) Pathway Is Associated with Frailty in Egyptian Elderly
Author/Authors :
Mohamad , Magda Medical Biochemistry Department - Faculty of Medicine - Ain Shams University - Cairo, Egypt , Ebeid , Somaia Geriatrics and Gerontology Department - Faculty of Medicine - Ain Shams University - Cairo, Egypt , Khater , Mohamed Shawky Geriatrics and Gerontology Department - Faculty of Medicine - Ain Shams University - Cairo, Egypt , Alsadany , Mohamad Geriatrics and Gerontology Department - Faculty of Medicine - Ain Shams University - Cairo, Egypt
Abstract :
Chronic low-grade inflammation may be a cardinal pathophysiologic feature in the pathogenesis of
frailty. Interferon-gamma (INF-γ) is an understudied proinflammatory cytokine in frailty that induces many
inflammatory pathways including the guanosine triphosphate cyclohydrolase 1 (GTP-CH1) pathway. Our aim was
to evaluate the GTP-CH1 pathway in Egyptian frail elderly subjects.
Methods: INF-γ, neopterin, and nitric oxide (NO) levels were measured in 80 participants.
Results: Both pre-frail and frail subjects had significantly higher levels of INF-γ, neopterin and lower levels of NO
than the control group. These biomarkers were associated with the risk of frailty with significant odds ratio.
Conclusions: Elevated INF-γ levels in frail subjects may activate the GTP-CH1 pathway. Elevated neopterin
and reduced NO levels correlated with an active GTP-CH1 pathway. The risk of frailty increased with elevated
INF-γ and neopterin and decreased with elevated NO levels.
Keywords :
INF-γ , GTP-CH1 pathway , Frailty
Journal title :
Reports of Biochemistry and Molecular Biology (RBMB)
