Assessment of Correlation Between miR-210 Expression and Pre-Eclampsia Risk: A Meta-Analysis

Pre-eclampsia (PE) is a pregnancy disorder characterized by hypertension and proteinuria. The evidence has suggested that microRNAs (miRs) are associated with pre-eclampsia pathogenesis; however, these results are inconsistent. The aim of this study was to assess the association between miR-210 expression and PE risk. Methods: Previous studies were selected using PubMed, Scopus, MEDLINE, EMBASE, Science Direct, Google Scholar, Directory of Open Access Journals (DOAJ), and Scientific Information Database (SID). This metaanalysis includes 12 studies associated with miR-210 and pre-eclampsia and necessary information was extracted. Results: The standardized mean differences [(SMD (0.32) 95% CI (014–0.49), p=0.97] and heterogeneity were determined with the chi-square test (Q=3.63 df =11 p= 0.97), which found no heterogeneity between these studies. Additionally, publication bias was evaluated by Egger’s and Begg´s tests. Visual inspection of the funnel plot graphically, and statistically with Egger’s weighted regression [(p= 0.35) (95% CI -0.90 – 2.29)] and Begg’s rank correlation (p= 0.21), found no important publication bias between studies within the meta-analysis. Conclusions: Our findings suggest that miR-210 contributes to the pathogenesis of PE; therefore, miR-210 could serve as a novel biomarker to predict PE pathophysiology. Further studies are required in this field to characterize the mechanism involved in this process.