Title of article :
The role of mast cells, C-fibers, and cholinergic transmission in the reduction of tracheal muscle and mronchi of sensitized animal
Author/Authors :
Kirilina, V.M. Department of Life Safety and Health-saving Technologies - Federal State Budgetary Educational Institution of Higher Education «Petrozavodsk State Universitym , Petrozavodsk - The Republic of Karelia - the city of Petrozavodsk, Russia , Blazhevich, L.E. Department of Life Safety and Health - saving Technologies - Federal State Budgetary Educational Institution of Higher Education «Petrozavodsk State Universitym , Petrozavodsk - The Republic of Karelia - the city of Petrozavodsk, Russia , Smirnova, O.E. Department of Life Safety and Health. saving Technologies - Federal State Budgetary Educational Institution of Higher Education «Petrozavodsk State Universitym , Petrozavodsk - The Republic of Karelia - the city of Petrozavodsk, Russia
Abstract :
The article considers the role of stabilization of mast cell membranes, blockade of neuromuscular transmission and inactivation of C-fibers in the contractile activity of smooth muscles of the trachea and bronchi of sensitized rats. The studies were conducted on isolated preparations using electrical stimulation of postganglionic nerves (frequency - 30 stim/s, duration - 0.5 ms, amplitude - 20 V, duration of stimulation - 10 s). The study used cromolyn sodium, atropine, and capsaicin. As a result of the experiments, it was found that the leading role in the contraction of the muscles of the trachea and bronchi of a sensitized rat belongs to mast cells. However, the maximum effect of normalization of smooth muscle contraction can be achieved only in the case of a complex effect - blockade of neuromuscular transmission, stabilization of mast cell membranes, and inactivation of C-fibers.
Keywords :
Romolyn sodium , Atropine , Capsaicin , Acetylcholine receptor blockade , Electrical stimulation , Postganglionic nerves
Journal title :
Caspian Journal of Environmental Sciences (CJES)
