Author/Authors :
Ghayour-Mobarhan , Majid Metabolic Syndrome Research Center - School of Medicine - Mashhad University of Medical Sciences - Mashhad, Iran , Sadabadi , Fatemeh Metabolic Syndrome Research Center - School of Medicine - Mashhad University of Medical Sciences - Mashhad, Iran , Javandoost , Ali Metabolic Syndrome Research Center - School of Medicine - Mashhad University of Medical Sciences - Mashhad, Iran , Asadi , Zahra Metabolic Syndrome Research Center - School of Medicine - Mashhad University of Medical Sciences - Mashhad, Iran , Samadi , Sara Metabolic Syndrome Research Center - School of Medicine - Mashhad University of Medical Sciences - Mashhad, Iran , Saberi-Karimian , Maryam Metabolic Syndrome Research Center - School of Medicine - Mashhad University of Medical Sciences - Mashhad, Iran , Darroudi , Susan Metabolic Syndrome Research Center - School of Medicine - Mashhad University of Medical Sciences - Mashhad, Iran , Rahmani , Farzad Metabolic Syndrome Research Center - School of Medicine - Mashhad University of Medical Sciences - Mashhad, Iran , Jafari Sheshtamad ,Fatemehalsadat Metabolic Syndrome Research Center - School of Medicine - Mashhad University of Medical Sciences - Mashhad, Iran , Gholoobi , Aida Medical Genetics Research Centre - School of Medicine - Mashhad University of Medical Sciences - Mashhad, Iran , Heidari-Bakavol , Alireza Cardiovascular Research Center - School of Medicine - Mashhad University of Medical Sciences - Mashhad, Iran , Mouhebati , Mohsen Cardiovascular Research Center - School of Medicine - Mashhad University of Medical Sciences - Mashhad, Iran , Khorrami Mohebbseraj , Mohammad Sadegh Department of Medical Genetic and Molecular Medicine - School of Medicine - Mashhad University of Medical Sciences - Mashhad, Iran , Malekzadeh Gonabadi , Najmeh Department of genetic - School of science - Sistan and Baluchestan University - Zahedan, Iran , Bahrami , Afsane Cellular and Molecular Research Center - Birjand University of Medical Sciences - Birjand, Iran , Ferns , Gordon Department of Medical Education - Brighton & Sussex Medical School - Brighton - BN1 9PH, UK , Esmaeili , Habibollah Department of Biostatistics & Epidemiology - School of Health - Management & Social Determinants of Health Research Center - Mashhad University of Medical Sciences - Mashhad, Iran
Abstract :
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally, and
specifically in Iran. Generally, diabetes mellitus is the result of impaired glucose tolerance which together with
dyslipidemia are considered as important risk factors of CVD.
The aim of this study was to determine the relationship between fasting serum glucose (FSG), lipid profile and
CVD endpoints, and to establish an optimal FSG cut-off in the MASHAD cohort study after nearly 6 years of
follow-up.
Methods: All the participants of MASHAD study were followed up for 6 years to determine their
cardiovascular status. FSG, fasting lipids, and physical examinations were all recorded. To identify the
optimal cut- off point of FSG, we carried out receiver operating curve (ROC) analysis
Results: We determined MASHAD cutoff point of blood glucose as 90 mg/dl predicting the CVD outcome. The
sensitivity and specificity of the FSG criterion were 54.34% and 71.68%, respectively. The AUC was 0.665 (95%
CI 0.656-0.675, P< 0.0001). The adjusted hazard ratio show that FSG is associated with 2.34 increase in CVD
risk using MASHAD cutoff point (HR 2.34, 95% 1.73–3.17, P< 0.001).
Conclusions: These findings suggest that not only FSG and lipid profile are related to CVD outcome in the
MASHAD study, but also elevated fasting glucose levels is strongly associated with cardiovascular events in
this population. Besides, the fasting glucose at a threshold of 90 mg/dl can be used for screening cardiovascular
events among the Iranian population
