Author/Authors :
Khalilzadeh, Soheila shahid beheshti university - Department of Pediatrics, تهران, ايران , Karimi, Shirin shahid beheshti university - Mycobateriology Research Center - Department of Clinical Anatomical Pathology, تهران, ايران , Fakharian, Atefeh shahid beheshti university - Department of Internal Medicine, تهران, ايران , Hakimi, Shahin shahid beheshti university - Department of Pediatrics, تهران, ايران
Abstract :
Sinus histiocytosis with massive lymphadenopathy (SHML), Rosai-Dorfman Disease, is a rare histiocytic syndrome first described by Rosai and Dorfman, seen predominantly in childhood and early adulthood. Even though it is considered a benign disease, fatalities may occur due to cellular infiltrates of SHML. We report a 16–year–old boy with signs of polydypsia, polyuria, weight loss and generalized lymphadenopathy. He had been receiving corticosteroid following the diagnosis of histiocytosis X. Due to hyperglycemia, the patient was admitted with the primary diagnosis of diabetic ketoacidosis and medications were initiated. All paraclinical and immunologic examinations were negative. Axillary lymph node biopsy revealed the diagnosis of Rosai–Dorfman disease.
Keywords :
Rosai–Dorfman disease , Diabetes mellitus , histiocytosis X , Children.
