Author/Authors :
Gupta, Abhaya Department of Periodontology - Faculty of Dental Sciences - King George’s Medical University, Uttar Pradesh, Lucknow, India , Singh, Neetu Department of Molecular Biology - Center for Advanced Research -King George’s Medical University, Uttar Pradesh, Lucknow, India , Kumar, Anil Department of Molecular Biology - Center for Advanced Research -King George’s Medical University, Uttar Pradesh, Lucknow, India , Pratap Verma, Umesh Department of Periodontology - Faculty of Dental Sciences - King George’s Medical University, Uttar Pradesh, Lucknow, India , Kumar Verma, Ajay Department of Respiratory Medicine - King George’s Medical University, Uttar Pradesh, Lucknow, India , Shyam, Hari Department of Molecular Biology - Center for Advanced Research -King George’s Medical University, Uttar Pradesh, Lucknow, India , Lal, Nand Department of Periodontology - Faculty of Dental Sciences - King George’s Medical University, Uttar Pradesh, Lucknow, India , Kant, Surya Department of Respiratory Medicine - King George’s Medical University, Uttar Pradesh, Lucknow, India , Kumari, Ankur Department of Periodontology - Faculty of Dental Sciences - King George’s Medical University, Uttar Pradesh, Lucknow, India
Abstract :
The study aimed to investigate differential expression of targeted inflammatory-immune responsive genes [LTA, LTB, TNFSF4, TNFSF11/RANKL, TNFSF13, TNFSF13B, TNFRSF11B/ Osteoprotegerin; OPG and GFPT1/GFA ] in gingival tissues of bronchiectasis patients having chronic periodontitis in North central Indian population. Gingival tissues were collected from 30 systemically healthy chronic periodontitis patients (CP), 30 bronchiectasis patients with chronic periodontitis (B+CP), 3 systemically healthy with healthy gingiva (healthy control; HC) and 3 bronchiectasis with healthy gingiva (bronchiectasis control; BC). Statistical analysis revealed 7 genes to be significantly upregulated on comparing CP with B+CP i.e LTA (P<0.0001) in B+CP while LTB (P<0.0001), TNFSF4 (P=0.0003), TNFSF11 (P<0.0001), TNFSF13 (P=0.0003), TNFSF13B (P<0.0001) and TNFRSF11B (P=0.0004) in CP group. LTA (Lymphotoxin A) gene could be a potential genetic marker in bronchiectasis patients with chronic periodontitis.
Keywords :
Tumor necrosis factor superfamily , Lymphotoxin A gene , Bronchiectasis , Chronic periodontitis , Expression
