Author/Authors :
lravani, M tehran university of medical sciences tums, تهران, ايران , Mohebbi, B tehran university of medical sciences tums, تهران, ايران , Alimoghadam, K tehran university of medical sciences tums, تهران, ايران , Moosavi, A tehran university of medical sciences tums, تهران, ايران , Najar-Najafi, S tehran university of medical sciences tums, تهران, ايران , Ardalan, A tehran university of medical sciences tums, تهران, ايران , Ghavamzadeh, A tehran university of medical sciences tums, تهران, ايران
Abstract :
Interleukin-10 (lL-10) is a potent immunosuppressor which inhibits alloantigenic T cell response. IL-10 is also an anti-inflammatory endogenous cytokine. To investigate the predictive significance of endogenous IL-1 0 for acute graft versus host disease (GVHD) following allogeneic bone marrow transplantation (BMT), we performed a prospective study on spontaneous IL-10 production in the senlm of 96 patients admitted for allogeneic BMT. High spontaneous IL-1 0 production at the time of admission and prior to any preparative treatment correlates with a subsequent low incidence of G\THD as compared to patients with low IL-IO production. Our data demonstrate the predictive significance of increased IL-10 production in BMT patients and suggest a role for it in maintaining immunobalance in the setting of allogenic BMT.
Keywords :
Bone marrow transplantation , interleukin , IO , graft versus host disease , bone marrow transplantation
