A COMPARISON OF CLOMIPHENE CITRATE AND SEQUENTIAL CLOMIPHENE CITRATE PLUS HUMAN MENOPAUSAL GONADOTROPIN FOR USE IN CONJUNCTION WITH INTRAUTERINE INSEMINATION

There are currently many different protocols in use for controlled ovarian hyperstimulation (COR), but the optimal method has not yet been determined. To compare the outcome of COH using clomiphene citrate (CC) versus CC plus human menopausal gonadotropin (hMG) in conjunction with intrauterine insemination (lUI), we studied 117 infertile couples. lUI with CC was used in 92 cycles (group A) and lUI with CC plus hMG was used in 66 cycles (group B). Data analysis demonstrated no significant difference between the two groups with respect to patients age, duration and type of infertility, prior COll and endometrial thickness and pattern. Group A had a little longer follicular phase length than group B. Pregnancy rate for group A and B were 6.52% and 12.12%, respectively (P= 0.22). Endometrial pattern and thickness had no impact on pregnancy rate. There were no multiple gestation and obvious hyperstimulation syndrome. For patients undergoing controlled ovarian hyperstimulation with IUT. CC plus hMG protocol yields higher pregnancy rate than one using CC, although this difference was not statistically significant because of limitation of number of cycles.