WARFARIN INDUCED MASSIVE AND BILATERAL SKIN NECROSIS OF THE BREASTS: A CASE REPORT AND REVIEW OF THE LITERATURES

Warfarin induced skin necrosis is a rare complication associated with the use of oral anticoagulants. Most patients develop this complication at the initiation of therapy. The complication is usually associated with an underlying thrombophilia. We described a case of 75 year old patient who developed skin necrosis in her both breasts during warfarin treatment for a deep vein thrombosis. Thrombophilia screen demonstrated the presence of protein S and antithrombin III deficiency. The necrotic lesion was excised and defects eventually covered with skin flaps.