Title of article :
Circulating levels of IGF-I and IGFBP-3 in gastric cancer
Author/Authors :
altinkaynak, konca regional education and research hospital - department of biochemistry, TURKEY , bilici, mehmet atatürk university - faculty of medicine - department of oncology, TURKEY , bakan, nuri atatürk university - faculty of medicine - department of biochemistry, TURKEY , akçay, fatih atatürk university - faculty of medicine - department of biochemistry, TURKEY
Abstract :
Aim: To explore the causative mechanism of gastric carcinoma and to investigate the roles of circulating IGF-I and IGFBP-3 in gastric cancer. Materials and methods: Serum IGF-I and IGFBP-3 concentrations were measured using a 2-site coated tube immunoradiometric assay. Results: Serum IGF-I and IGFBP-3 values in gastric cancer patients were significantly lower compared to those in the control group. The difference between serum IGF-I/IGFBP-3 in patients and the control group was not significant. Conclusion: The low serum IGF-I and IGFBP-3 levels detected in patients with gastric cancer could be due to decreased synthesis or increased catabolism of IGF-I or both. It could be suggested that these parameters may be important in the development and prognosis of gastric cancer.
Keywords :
Insulin , like growth factors , insulin , like growth factor , 1 , stage , gastric cancer
Journal title :
Turkish Journal of Medical Sciences (TJMS)
Journal title :
Turkish Journal of Medical Sciences (TJMS)
